An mGlu5-Positive Allosteric Modulator Rescues the Neuroplasticity Deficits in a Genetic Model of NMDA Receptor Hypofunction in Schizophrenia.

Balu DT, Li Y, Takagi S, Presti KT, Ramikie TS, Rook JM, Jones CK, Lindsley CW, Conn PJ, Bolshakov VY, Coyle JT
Neuropsychopharmacology. 2016 41 (8): 2052-61

PMID: 26741285 · PMCID: PMC4908650 · DOI:10.1038/npp.2016.2

MeSH Terms (16)

Allosteric Regulation Animals Disease Models, Animal Hippocampus Male Mice, Inbred C57BL Mice, Knockout Neuronal Plasticity Oxazoles Proto-Oncogene Proteins c-akt Pyridines Racemases and Epimerases Receptor, Metabotropic Glutamate 5 Receptors, N-Methyl-D-Aspartate Schizophrenia Signal Transduction

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