Conservative Secondary Shell Substitution In Cyclooxygenase-2 Reduces Inhibition by Indomethacin Amides and Esters via Altered Enzyme Dynamics.

Konkle ME, Blobaum AL, Moth CW, Prusakiewicz JJ, Xu S, Ghebreselasie K, Akingbade D, Jacobs AT, Rouzer CA, Lybrand TP, Marnett LJ
Biochemistry. 2016 55 (2): 348-59

PMID: 26704937 · PMCID: PMC4721528 · DOI:10.1021/acs.biochem.5b01222

MeSH Terms (8)

Amides Computational Biology Cyclooxygenase 2 Enzyme Activation Esters Indomethacin Protein Structure, Secondary Structure-Activity Relationship

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