Preliminary investigation of 6,7-dihydropyrazolo[1,5-a]pyrazin-4-one derivatives as a novel series of mGlu5 receptor positive allosteric modulators with efficacy in preclinical models of schizophrenia.

Conde-Ceide S, Alcázar J, Alonso de Diego SA, López S, Martín-Martín ML, Martínez-Viturro CM, Pena MA, Tong HM, Lavreysen H, Mackie C, Bridges TM, Daniels JS, Niswender CM, Jones CK, Macdonald GJ, Steckler T, Conn PJ, Stauffer SR, Lindsley CW, Bartolomé-Nebreda JM
Bioorg Med Chem Lett. 2016 26 (2): 429-434

PMID: 26684851 · PMCID: PMC4835042 · DOI:10.1016/j.bmcl.2015.11.098

MeSH Terms (11)

Allosteric Regulation Animals Antipsychotic Agents HEK293 Cells Humans Male Pyrazines Pyrazoles Rats, Sprague-Dawley Receptor, Metabotropic Glutamate 5 Schizophrenia

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