Clinical Candidate VT-1161's Antiparasitic Effect In Vitro, Activity in a Murine Model of Chagas Disease, and Structural Characterization in Complex with the Target Enzyme CYP51 from Trypanosoma cruzi.

Hoekstra WJ, Hargrove TY, Wawrzak Z, da Gama Jaen Batista D, da Silva CF, Nefertiti AS, Rachakonda G, Schotzinger RJ, Villalta F, Soeiro Mde N, Lepesheva GI
Antimicrob Agents Chemother. 2016 60 (2): 1058-66

PMID: 26643331 · PMCID: PMC4750653 · DOI:10.1128/AAC.02287-15

MeSH Terms (15)

14-alpha Demethylase Inhibitors Animals Chagas Disease Crystallography, X-Ray Disease Models, Animal Female Heme Mice Models, Molecular Protein Conformation Pyridines Sterol 14-Demethylase Tetrazoles Trypanocidal Agents Trypanosoma cruzi

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