M1 and M3 muscarinic receptors may play a role in the neurotoxicity of anhydroecgonine methyl ester, a cocaine pyrolysis product.

Garcia RC, Dati LM, Torres LH, da Silva MA, Udo MS, Abdalla FM, da Costa JL, Gorj√£o R, Afeche SC, Yonamine M, Niswender CM, Conn PJ, Camarini R, Sandoval MR, Marcourakis T
Sci Rep. 2015 5: 17555

PMID: 26626425 · PMCID: PMC4667193 · DOI:10.1038/srep17555

MeSH Terms (15)

Animals Apoptosis CHO Cells Cocaine Cricetinae Cricetulus DNA Fragmentation Female Hippocampus Neurotoxicity Syndromes Neurotoxins Rats Receptor, Muscarinic M1 Receptor, Muscarinic M3 Time Factors

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