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The Etiologic Role of Infectious Antigens in Sarcoidosis Pathogenesis.

Celada LJ, Hawkins C, Drake WP
Clin Chest Med. 2015 36 (4): 561-8

PMID: 26593133 · PMCID: PMC4660257 · DOI:10.1016/j.ccm.2015.08.001

Sarcoidosis is a granulomatous disease of unknown etiology, most commonly involving the lung, skin, lymph node, and eyes. Molecular and immunologic studies continue to strengthen the association of sarcoidosis with infectious antigens. Independent studies report the presence of microbial nucleic acids and proteins within sarcoidosis specimens. Complementary immunologic studies also support the role of infectious agents in sarcoidosis pathogenesis. Case reports and clinical trials have emerged regarding the efficacy of antimicrobials. They support increasing efforts to identify novel therapeutics, such as antimicrobials, that will have an impact on the observed increase in sarcoidosis morbidity and mortality.

Copyright © 2015 Elsevier Inc. All rights reserved.

MeSH Terms (5)

Anti-Infective Agents Granuloma Humans Lung Sarcoidosis

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