Competition between the Brain and Testes under Selenium-Compromised Conditions: Insight into Sex Differences in Selenium Metabolism and Risk of Neurodevelopmental Disease.

Pitts MW, Kremer PM, Hashimoto AC, Torres DJ, Byrns CN, Williams CS, Berry MJ
J Neurosci. 2015 35 (46): 15326-38

PMID: 26586820 · PMCID: PMC4649005 · DOI:10.1523/JNEUROSCI.2724-15.2015

UNLABELLED - Selenium (Se) is essential for both brain development and male fertility. Male mice lacking two key genes involved in Se metabolism (Scly(-/-)Sepp1(-/-) mice), selenoprotein P (Sepp1) and Sec lyase (Scly), develop severe neurological dysfunction, neurodegeneration, and audiogenic seizures that manifest beginning in early adulthood. We demonstrate that prepubescent castration of Scly(-/-)Sepp1(-/-) mice prevents behavioral deficits, attenuates neurodegeneration, rescues maturation of GABAergic inhibition, and increases brain selenoprotein levels. Moreover, castration also yields similar neuroprotective benefits to Sepp1(-/-) and wild-type mice challenged with Se-deficient diets. Our data show that, under Se-compromised conditions, the brain and testes compete for Se utilization, with concomitant effects on neurodevelopment and neurodegeneration.

SIGNIFICANCE STATEMENT - Selenium is an essential trace element that promotes male fertility and brain function. Herein, we report that prepubescent castration provides neuroprotection by increasing selenium-dependent antioxidant activity in the brain, revealing a competition between the brain and testes for selenium utilization. These findings provide novel insight into the interaction of sex and oxidative stress upon the developing brain and have potentially significant implications for the prevention of neurodevelopmental disorders characterized by aberrant excitatory/inhibitory balance, such as schizophrenia and epilepsy.

Copyright © 2015 the authors 0270-6474/15/3515326-13$15.00/0.

MeSH Terms (23)

Age Factors Animals Brain Castration Dizocilpine Maleate Epilepsy, Reflex Exploratory Behavior Female Gene Expression Regulation Glutamate Decarboxylase Lyases Male Maze Learning Mice Mice, Inbred C57BL Mice, Transgenic Motor Activity Nerve Tissue Proteins Neurodevelopmental Disorders Selenium Selenoprotein P Sex Factors Transcription Factors

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