InsR/IGF1R Pathway Mediates Resistance to EGFR Inhibitors in Glioblastoma.

Ma Y, Tang N, Thompson RC, Mobley BC, Clark SW, Sarkaria JN, Wang J
Clin Cancer Res. 2016 22 (7): 1767-76

PMID: 26561558 · PMCID: PMC4818693 · DOI:10.1158/1078-0432.CCR-15-1677

MeSH Terms (20)

Animals Antineoplastic Agents Cell Line, Tumor Disease Models, Animal Drug Resistance, Neoplasm ErbB Receptors Gefitinib Glioblastoma Humans Insulin Insulin-Like Growth Factor I Mice Protein Kinase Inhibitors Proto-Oncogene Proteins c-akt Quinazolines Receptor, IGF Type 1 Receptor, Insulin Signal Transduction Tumor Burden Xenograft Model Antitumor Assays

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