Inactivating the permanent neonatal diabetes gene Mnx1 switches insulin-producing β-cells to a δ-like fate and reveals a facultative proliferative capacity in aged β-cells.

Pan FC, Brissova M, Powers AC, Pfaff S, Wright CV
Development. 2015 142 (21): 3637-48

PMID: 26534984 · PMCID: PMC4647212 · DOI:10.1242/dev.126011

MeSH Terms (15)

Animals Cell Transdifferentiation Cellular Senescence Diabetes Mellitus Eye Proteins Homeodomain Proteins Humans Hyperplasia Insulin-Secreting Cells Mice Paired Box Transcription Factors PAX6 Transcription Factor Repressor Proteins Somatostatin-Secreting Cells Transcription Factors

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