The Relationship between Total Fibroid Burden and First Trimester Bleeding and Pain.

Michels KA, Hartmann KE, Archer KR, Ye F, Edwards DR
Paediatr Perinat Epidemiol. 2016 30 (2): 115-23

PMID: 26525634 · PMCID: PMC4749406 · DOI:10.1111/ppe.12256

BACKGROUND - Few studies comment on the association between fibroids and symptoms among pregnant women. These studies generally are retrospective and do not to assess the influence of number of tumours or their volume on risk of symptoms.

METHODS - Right from the Start is a prospective cohort that enrolled pregnant women from the southeastern USA between 2000 and 2012. In the first trimester, all participants had standardised ultrasounds to determine the presence or absence of fibroids. Symptoms were queried in a telephone survey. We used polytomous logistic regression to model odds of bleeding, pain, or both symptoms in relation to increasing total fibroid number and volume among white and black women.

RESULTS - Among 4509 participants, the prevalence of fibroids was 11%. Among those reporting symptoms (70%), 11% reported only bleeding, 59% reported only pain, and 30% reported both symptoms. After adjusting for age, race, parity, hypertension, smoking, alcohol use, and study site, increasing number of fibroids was associated with pain [odds ratio (OR) 1.16, 95% confidence interval (CI) 1.00, 1.33] and both symptoms [OR 1.25, 95% CI 1.08, 1.45] but not with bleeding among all women. Fibroid volume was not associated with symptoms among black women, but white women with the smallest fibroid volumes were more likely to report both symptoms than those without fibroids [OR 1.79, 95% CI 1.17, 2.72].

CONCLUSIONS - Very large tumours are not requisite for experiencing symptoms, as small fibroids and increasing number of tumours are associated with pain and both symptoms.

© 2015 John Wiley & Sons Ltd.

MeSH Terms (16)

Adolescent Adult African Americans European Continental Ancestry Group Female Humans Pain Pregnancy Pregnancy Complications, Cardiovascular Pregnancy Complications, Neoplastic Pregnancy Trimester, First Prospective Studies United States Uterine Hemorrhage Uterine Neoplasms Young Adult

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