Design of 4-Oxo-1-aryl-1,4-dihydroquinoline-3-carboxamides as Selective Negative Allosteric Modulators of Metabotropic Glutamate Receptor Subtype 2.

Felts AS, Rodriguez AL, Smith KA, Engers JL, Morrison RD, Byers FW, Blobaum AL, Locuson CW, Chang S, Venable DF, Niswender CM, Daniels JS, Conn PJ, Lindsley CW, Emmitte KA
J Med Chem. 2015 58 (22): 9027-40

PMID: 26524606 · PMCID: PMC4817271 · DOI:10.1021/acs.jmedchem.5b01371

MeSH Terms (11)

Animals Central Nervous System Drug Discovery Mice Protein Binding Quinolines Quinolones Rats Receptor, Muscarinic M1 Receptors, Metabotropic Glutamate Structure-Activity Relationship

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