Allosteric activation of M4 muscarinic receptors improve behavioral and physiological alterations in early symptomatic YAC128 mice.

Pancani T, Foster DJ, Moehle MS, Bichell TJ, Bradley E, Bridges TM, Klar R, Poslusney M, Rook JM, Daniels JS, Niswender CM, Jones CK, Wood MR, Bowman AB, Lindsley CW, Xiang Z, Conn PJ
Proc Natl Acad Sci U S A. 2015 112 (45): 14078-83

PMID: 26508634 · PMCID: PMC4653197 · DOI:10.1073/pnas.1512812112

MeSH Terms (14)

Allosteric Regulation Animals Brain Fluorescence Glutamic Acid Huntington Disease Immunohistochemistry Mice Mice, Mutant Strains Pyridazines Receptor, Muscarinic M4 Rotarod Performance Test Synaptic Transmission Thiophenes

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