VU0477573: Partial Negative Allosteric Modulator of the Subtype 5 Metabotropic Glutamate Receptor with In Vivo Efficacy.

Nickols HH, Yuh JP, Gregory KJ, Morrison RD, Bates BS, Stauffer SR, Emmitte KA, Bubser M, Peng W, Nedelcovych MT, Thompson A, Lv X, Xiang Z, Daniels JS, Niswender CM, Lindsley CW, Jones CK, Conn PJ
J Pharmacol Exp Ther. 2016 356 (1): 123-36

PMID: 26503377 · PMCID: PMC4702078 · DOI:10.1124/jpet.115.226597

MeSH Terms (22)

Allosteric Regulation Animals Anti-Anxiety Agents Astrocytes Behavior, Animal Brain Dose-Response Relationship, Drug Drug Discovery GABA Agonists HEK293 Cells Humans Inositol Phosphates MAP Kinase Signaling System Membrane Potentials Mice Mice, Inbred C57BL Picolinic Acids Pyridines Radioligand Assay Rats Receptor, Metabotropic Glutamate 5 Synaptic Transmission

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