Simulation of Human Plasma Concentrations of Thalidomide and Primary 5-Hydroxylated Metabolites Explored with Pharmacokinetic Data in Humanized TK-NOG Mice.

Nishiyama S, Suemizu H, Shibata N, Guengerich FP, Yamazaki H
Chem Res Toxicol. 2015 28 (11): 2088-90

PMID: 26492539 · PMCID: PMC6345571 · DOI:10.1021/acs.chemrestox.5b00381

MeSH Terms (10)

Animals Cytochrome P-450 CYP3A Glutathione Hepatocytes Humans Hydroxylation Liver Mice Teratogens Thalidomide

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