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Comparison of three neurotropic viruses reveals differences in viral dissemination to the central nervous system.

Luethy LN, Erickson AK, Jesudhasan PR, Ikizler M, Dermody TS, Pfeiffer JK
Virology. 2016 487: 1-10

PMID: 26479325 · PMCID: PMC4679581 · DOI:10.1016/j.virol.2015.09.019

Neurotropic viruses initiate infection in peripheral tissues prior to entry into the central nervous system (CNS). However, mechanisms of dissemination are not completely understood. We used genetically marked viruses to compare dissemination of poliovirus, yellow fever virus 17D (YFV-17D), and reovirus type 3 Dearing in mice from a hind limb intramuscular inoculation site to the sciatic nerve, spinal cord, and brain. While YFV-17D likely entered the CNS via blood, poliovirus and reovirus likely entered the CNS by transport through the sciatic nerve to the spinal cord. We found that dissemination was inefficient in adult immune-competent mice for all three viruses, particularly reovirus. Dissemination of all viruses was more efficient in immune-deficient mice. Although poliovirus and reovirus both accessed the CNS by transit through the sciatic nerve, stimulation of neuronal transport by muscle damage enhanced dissemination only of poliovirus. Our results suggest that these viruses access the CNS using different pathways.

Copyright © 2015 Elsevier Inc. All rights reserved.

MeSH Terms (19)

Animals Cell Line Central Nervous System Cricetinae HeLa Cells Humans Interferon Type I Mice Mice, Inbred C57BL Mice, Knockout Orthoreovirus, Mammalian Peripheral Nerves Poliomyelitis Poliovirus Receptor, Interferon alpha-beta Reoviridae Infections Sciatic Nerve Yellow Fever Yellow fever virus

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