Lead optimization of the VU0486321 series of mGlu1 PAMs. Part 1: SAR of modifications to the central aryl core.

Garcia-Barrantes PM, Cho HP, Blobaum AL, Niswender CM, Conn PJ, Lindsley CW
Bioorg Med Chem Lett. 2015 25 (22): 5107-10

PMID: 26476971 · PMCID: PMC4758672 · DOI:10.1016/j.bmcl.2015.10.013

MeSH Terms (12)

Allosteric Regulation Animals Brain Coumarins Furans Humans Microsomes, Liver Phthalimides Rats Receptors, Metabotropic Glutamate Stereoisomerism Structure-Activity Relationship

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