Acyl dihydropyrazolo[1,5-a]pyrimidinones as metabotropic glutamate receptor 5 positive allosteric modulators.

Malosh C, Turlington M, Bridges TM, Rook JM, Noetzel MJ, Vinson PN, Steckler T, Lavreysen H, Mackie C, Bartolomé-Nebreda JM, Conde-Ceide S, Martínez-Viturro CM, Piedrafita M, Sánchez-Casado MR, Macdonald GJ, Daniels JS, Jones CK, Niswender CM, Conn PJ, Lindsley CW, Stauffer SR
Bioorg Med Chem Lett. 2015 25 (22): 5115-20

PMID: 26475522 · PMCID: PMC4634704 · DOI:10.1016/j.bmcl.2015.10.009

MeSH Terms (15)

Allosteric Regulation Animals Brain Dogs Humans Ligands Male Motor Activity Pyrazoles Pyrimidines Pyrimidinones Rats Rats, Sprague-Dawley Receptor, Metabotropic Glutamate 5 Structure-Activity Relationship

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