, a bio/informatics shared resource is still "open for business" - Visit the CDS website

Publication

Cumulative Incidence of Cancer Among Persons With HIV in North America: A Cohort Study.

Silverberg MJ, Lau B, Achenbach CJ, Jing Y, Althoff KN, D'Souza G, Engels EA, Hessol NA, Brooks JT, Burchell AN, Gill MJ, Goedert JJ, Hogg R, Horberg MA, Kirk GD, Kitahata MM, Korthuis PT, Mathews WC, Mayor A, Modur SP, Napravnik S, Novak RM, Patel P, Rachlis AR, Sterling TR, Willig JH, Justice AC, Moore RD, Dubrow R, North American AIDS Cohort Collaboration on Research and Design of the International Epidemiologic Databases to Evaluate AIDS
Ann Intern Med. 2015 163 (7): 507-18

PMID: 26436616 · PMCID: PMC4711936 · DOI:10.7326/M14-2768

BACKGROUND - Cancer is increasingly common among persons with HIV.

OBJECTIVE - To examine calendar trends in cumulative cancer incidence and hazard rate by HIV status.

DESIGN - Cohort study.

SETTING - North American AIDS Cohort Collaboration on Research and Design during 1996 to 2009.

PARTICIPANTS - 86 620 persons with HIV and 196 987 uninfected adults.

MEASUREMENTS - Cancer type-specific cumulative incidence by age 75 years and calendar trends in cumulative incidence and hazard rates, each by HIV status.

RESULTS - Cumulative incidences of cancer by age 75 years for persons with and without HIV, respectively, were as follows: Kaposi sarcoma, 4.4% and 0.01%; non-Hodgkin lymphoma, 4.5% and 0.7%; lung cancer, 3.4% and 2.8%; anal cancer, 1.5% and 0.05%; colorectal cancer, 1.0% and 1.5%; liver cancer, 1.1% and 0.4%; Hodgkin lymphoma, 0.9% and 0.09%; melanoma, 0.5% and 0.6%; and oral cavity/pharyngeal cancer, 0.8% and 0.8%. Among persons with HIV, calendar trends in cumulative incidence and hazard rate decreased for Kaposi sarcoma and non-Hodgkin lymphoma. For anal, colorectal, and liver cancer, increasing cumulative incidence, but not hazard rate trends, were due to the decreasing mortality rate trend (-9% per year), allowing greater opportunity to be diagnosed. Despite decreasing hazard rate trends for lung cancer, Hodgkin lymphoma, and melanoma, cumulative incidence trends were not seen because of the compensating effect of the declining mortality rate.

LIMITATION - Secular trends in screening, smoking, and viral co-infections were not evaluated.

CONCLUSION - Cumulative cancer incidence by age 75 years, approximating lifetime risk in persons with HIV, may have clinical utility in this population. The high cumulative incidences by age 75 years for Kaposi sarcoma, non-Hodgkin lymphoma, and lung cancer support early and sustained antiretroviral therapy and smoking cessation.

MeSH Terms (20)

Adult Aged Age Distribution Anus Neoplasms Cohort Studies Colorectal Neoplasms Comorbidity Female HIV Infections Humans Incidence Liver Neoplasms Lung Neoplasms Lymphoma, Non-Hodgkin Male Middle Aged Neoplasms North America Proportional Hazards Models Sarcoma, Kaposi

Connections (1)

This publication is referenced by other Labnodes entities:

Links