Development of Novel, CNS Penetrant Positive Allosteric Modulators for the Metabotropic Glutamate Receptor Subtype 1 (mGlu1), Based on an N-(3-Chloro-4-(1,3-dioxoisoindolin-2-yl)phenyl)-3-methylfuran-2-carboxamide Scaffold, That Potentiate Wild Type and Mutant mGlu1 Receptors Found in Schizophrenics.

Garcia-Barrantes PM, Cho HP, Niswender CM, Byers FW, Locuson CW, Blobaum AL, Xiang Z, Rook JM, Conn PJ, Lindsley CW
J Med Chem. 2015 58 (20): 7959-71

PMID: 26426481 · PMCID: PMC4839290 · DOI:10.1021/acs.jmedchem.5b00727

MeSH Terms (13)

Animals Central Nervous System Epilepsy GABA Agonists GABA Modulators Half-Life Humans Molecular Conformation Rats Receptor, Metabotropic Glutamate 5 Receptors, Metabotropic Glutamate Schizophrenia Structure-Activity Relationship

Connections (3)

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