Competition and allostery govern substrate selectivity of cyclooxygenase-2.

Mitchener MM, Hermanson DJ, Shockley EM, Brown HA, Lindsley CW, Reese J, Rouzer CA, Lopez CF, Marnett LJ
Proc Natl Acad Sci U S A. 2015 112 (40): 12366-71

PMID: 26392530 · PMCID: PMC4603459 · DOI:10.1073/pnas.1507307112

MeSH Terms (24)

Algorithms Allosteric Regulation Allosteric Site Animals Arachidonic Acid Arachidonic Acids Binding, Competitive Catalytic Domain Cell Line Computer Simulation Cyclooxygenase 2 Endocannabinoids Glycerides Kinetics Macrophages Mice Oxidation-Reduction Prostaglandins Protein Binding Protein Multimerization Sf9 Cells Spodoptera Substrate Specificity Zymosan

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