Parenteral Prostanoid Use at a Tertiary Referral Center: A Retrospective Cohort Study.

Hay BR, Pugh ME, Robbins IM, Hemnes AR
Chest. 2016 149 (3): 660-6

PMID: 26378379 · PMCID: PMC4944766 · DOI:10.1378/chest.15-1051

BACKGROUND - Evidence-based guidelines recommend the use of parenteral prostaglandin (PP) therapy in patients with advanced pulmonary arterial hypertension (PAH). Despite this, many patients with PAH die without PP therapy. We sought to examine the frequency of PP use at a large referral center and characterize patients with PAH who died without receiving PP.

METHODS - We conducted a single-center retrospective cohort analysis of consecutive patients with PAH between 2008 and 2012. Clinical data and cause of death were compared between patients with PAH treated with PP (PAH-PP) and those who were not but were not documented as poor PP candidates (PAH-nonPP).

RESULTS - Of the 101 patients who received a diagnosis of PAH and died, 61 received PP therapy. Of the 40 patients not treated with PP, 10 did not have documented evaluations for PP therapy (PAH-nonPP) whereas 30 were not considered candidates or refused PP therapy. Compared with PAH-PP, PAH-nonPP had a longer 6-min walk distance, had a longer duration between time of diagnosis and date of worse functional class visit, were less likely to be diagnosed as functional class IV, and had significantly lower right atrial pressure. None of the PAH-nonPP died of progressive PAH.

CONCLUSIONS - We found that most patients who die with PAH are evaluated for PP therapy at a large referral center and the small minority of PAH-nonPP tended to have less severe disease and die of non-PAH-related causes. Our data suggest that at large pulmonary hypertension (PH) centers, the vast majority of patients who are appropriate candidates receive PP therapy.

Copyright © 2016 American College of Chest Physicians. Published by Elsevier Inc. All rights reserved.

MeSH Terms (26)

Adult Cause of Death Cohort Studies Comorbidity Connective Tissue Diseases Death, Sudden Endothelin Receptor Antagonists Familial Primary Pulmonary Hypertension Female Guideline Adherence Heart Defects, Congenital Heart Failure HIV Infections Humans Hypertension, Pulmonary Infusions, Parenteral Male Middle Aged Patient Selection Phosphodiesterase 5 Inhibitors Practice Guidelines as Topic Prostaglandins Quality Improvement Retrospective Studies Severity of Illness Index Tertiary Care Centers

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