Regulation of contractile ring formation and septation in Schizosaccharomyces pombe.

Willet AH, McDonald NA, Gould KL
Curr Opin Microbiol. 2015 28: 46-52

PMID: 26340438 · PMCID: PMC4688203 · DOI:10.1016/j.mib.2015.08.001

The fission yeast Schizosaccharomyces pombe has become a powerful model organism for cytokinesis studies, propelled by pioneering genetic screens in the 1980s and 1990s. S. pombe cells are rod-shaped and divide similarly to mammalian cells, utilizing a medially-placed actin-and myosin-based contractile ring. A cell wall division septum is deposited behind the constricting ring, forming the new ends of each daughter cell. Here we discuss recent advances in our understanding of the regulation of contractile ring formation through formin proteins and the role of the division septum in S. pombe cell division.

Copyright © 2015 Elsevier Ltd. All rights reserved.

MeSH Terms (10)

Actins Cell Division Cell Wall Cytokinesis Cytoskeletal Proteins Gene Expression Regulation, Fungal Myosins Profilins Schizosaccharomyces Schizosaccharomyces pombe Proteins

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