Discovery of a Selective and CNS Penetrant Negative Allosteric Modulator of Metabotropic Glutamate Receptor Subtype 3 with Antidepressant and Anxiolytic Activity in Rodents.

Engers JL, Rodriguez AL, Konkol LC, Morrison RD, Thompson AD, Byers FW, Blobaum AL, Chang S, Venable DF, Loch MT, Niswender CM, Daniels JS, Jones CK, Conn PJ, Lindsley CW, Emmitte KA
J Med Chem. 2015 58 (18): 7485-500

PMID: 26335039 · PMCID: PMC4809247 · DOI:10.1021/acs.jmedchem.5b01005

MeSH Terms (18)

Allosteric Regulation Animals Anti-Anxiety Agents Antidepressive Agents Brain Calcium Dogs Heterocyclic Compounds, 2-Ring Humans Madin Darby Canine Kidney Cells Mice Microsomes, Liver Permeability Pyridines Rats Receptors, Metabotropic Glutamate Stereoisomerism Structure-Activity Relationship

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