Novel BAC Mouse Model of Huntington's Disease with 225 CAG Repeats Exhibits an Early Widespread and Stable Degenerative Phenotype.

Wegrzynowicz M, Bichell TJ, Soares BD, Loth MK, McGlothan JS, Mori S, Alikhan FS, Hua K, Coughlin JM, Holt HK, Jetter CS, Pomper MG, Osmand AP, Guilarte TR, Bowman AB
J Huntingtons Dis. 2015 4 (1): 17-36

PMID: 26333255 · PMCID: PMC4657874

MeSH Terms (16)

Animals Atrophy Behavior, Animal Brain Chromosomes, Artificial, Bacterial Disease Models, Animal Disease Progression Huntington Disease Mice Mice, Inbred C57BL Mice, Transgenic Neurons Phenotype Promoter Regions, Genetic Serotonin Plasma Membrane Transport Proteins Trinucleotide Repeat Expansion

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