A DLL3-targeted antibody-drug conjugate eradicates high-grade pulmonary neuroendocrine tumor-initiating cells in vivo.

Saunders LR, Bankovich AJ, Anderson WC, Aujay MA, Bheddah S, Black K, Desai R, Escarpe PA, Hampl J, Laysang A, Liu D, Lopez-Molina J, Milton M, Park A, Pysz MA, Shao H, Slingerland B, Torgov M, Williams SA, Foord O, Howard P, Jassem J, Badzio A, Czapiewski P, Harpole DH, Dowlati A, Massion PP, Travis WD, Pietanza MC, Poirier JT, Rudin CM, Stull RA, Dylla SJ
Sci Transl Med. 2015 7 (302): 302ra136

PMID: 26311731 · PMCID: PMC4934375 · DOI:10.1126/scitranslmed.aac9459

MeSH Terms (14)

Animals Antibodies, Monoclonal Antineoplastic Agents Female Humans Immunoconjugates Intracellular Signaling Peptides and Proteins Lung Neoplasms Membrane Proteins Mice Mice, Inbred NOD Mice, SCID Neuroendocrine Tumors Xenograft Model Antitumor Assays

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