RAS-MAPK dependence underlies a rational polytherapy strategy in EML4-ALK-positive lung cancer.

Hrustanovic G, Olivas V, Pazarentzos E, Tulpule A, Asthana S, Blakely CM, Okimoto RA, Lin L, Neel DS, Sabnis A, Flanagan J, Chan E, Varella-Garcia M, Aisner DL, Vaishnavi A, Ou SH, Collisson EA, Ichihara E, Mack PC, Lovly CM, Karachaliou N, Rosell R, Riess JW, Doebele RC, Bivona TG
Nat Med. 2015 21 (9): 1038-47

PMID: 26301689 · PMCID: PMC4734742 · DOI:10.1038/nm.3930

MeSH Terms (13)

Anaplastic Lymphoma Kinase Cell Line, Tumor Drug Resistance, Neoplasm Dual Specificity Phosphatase 6 Humans Lung Neoplasms Mitogen-Activated Protein Kinase Kinases Mitogen-Activated Protein Kinases Oncogene Proteins, Fusion Proto-Oncogene Proteins Proto-Oncogene Proteins p21(ras) ras Proteins Receptor Protein-Tyrosine Kinases

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