EGFR Kinase Domain Duplication (EGFR-KDD) Is a Novel Oncogenic Driver in Lung Cancer That Is Clinically Responsive to Afatinib.

Gallant JN, Sheehan JH, Shaver TM, Bailey M, Lipson D, Chandramohan R, Red Brewer M, York SJ, Kris MG, Pietenpol JA, Ladanyi M, Miller VA, Ali SM, Meiler J, Lovly CM
Cancer Discov. 2015 5 (11): 1155-63

PMID: 26286086 · PMCID: PMC4631701 · DOI:10.1158/2159-8290.CD-15-0654

MeSH Terms (21)

Adult Afatinib Antineoplastic Agents Drug Resistance, Neoplasm ErbB Receptors Gene Duplication Gene Frequency Humans Lung Neoplasms Male Models, Molecular Molecular Targeted Therapy Mutation Neoplasm Staging Protein Conformation Protein Interaction Domains and Motifs Protein Kinase Inhibitors Protein Multimerization Quinazolines Tomography, X-Ray Computed Treatment Outcome

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