PIPPing on AKT1: How Many Phosphatases Does It Take to Turn off PI3K?

Toker A, Rameh L
Cancer Cell. 2015 28 (2): 143-5

PMID: 26267528 · DOI:10.1016/j.ccell.2015.07.010

In this issue of Cancer Cell, Ooms and colleagues show that the lipid phosphatase PIPP/INPP5J, frequently inactivated in triple-negative breast cancers, functions as a tumor suppressor by specifically modulating the activity of AKT1 in the context of oncogenic PI3K signaling, leading to inhibition of metastatic dissemination.

Copyright © 2015 Elsevier Inc. All rights reserved.

MeSH Terms (6)

Animals Breast Neoplasms Cell Proliferation Humans Phosphoric Monoester Hydrolases Proto-Oncogene Proteins c-akt

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