A Screen of Approved Drugs Identifies the Androgen Receptor Antagonist Flutamide and Its Pharmacologically Active Metabolite 2-Hydroxy-Flutamide as Heterotropic Activators of Cytochrome P450 3A In Vitro and In Vivo.

Blobaum AL, Byers FW, Bridges TM, Locuson CW, Conn PJ, Lindsley CW, Daniels JS
Drug Metab Dispos. 2015 43 (11): 1718-26

PMID: 26265743 · PMCID: PMC4613951 · DOI:10.1124/dmd.115.064006

MeSH Terms (16)

Androgen Receptor Antagonists Animals Cytochrome P-450 CYP3A Drug Evaluation, Preclinical Enzyme Activators Female Flutamide Guinea Pigs Humans Male Mice Microsomes, Liver Rats Rats, Sprague-Dawley Swine Swine, Miniature

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