A Feedback Control Approach to Organic Drug Infusions Using Electrochemical Measurement.

Myers MH, Li Y, Kivlehan F, Lindner E, Chaum E
IEEE Trans Biomed Eng. 2016 63 (3): 506-11

PMID: 26258937 · DOI:10.1109/TBME.2015.2464771

GOAL - Target-controlled infusion of anesthesia is a closed-loop automated drug delivery method with a computer-aided control. Our goal is to design and test an automated drug infusion platform for propofol delivery in total intravenous anesthesia (TIVA) administration.

METHODS - In the proposed method, a dilution chamber with first-order exponential decay characteristics was used to model the pharmacodynamics decay of a drug. The dilution chamber was connected to a flow system through an electrochemical cell containing an organic film-coated glassy carbon electrode as working electrode. To set up the feedback-controlled delivery platform and optimize its parameters, ferrocene methanol was used as a proxy of the propofol. The output signal of the sensor was connected to a PI controller, which prompted a syringe pump for feedback-controlled drug infusion.

RESULTS - The result is a bench-top drug infusion platform to automate the delivery of a propofol based on the measurement of concentration with an organic film-coated voltammetric sensor.

CONCLUSION - To evaluate the performance characteristics of the infusion platform, the propofol concentration in the dilution chamber was monitored with the organic film-coated glassy carbon electrode and the difference between the set and measured concentrations was assessed. The feasibility of measurement-based feedback-controlled propofol delivery is demonstrated and confirmed.

SIGNIFICANCE - This platform will contribute to high-performance TIVA application of intravenous propofol anesthesia.

MeSH Terms (6)

Anesthesia, Intravenous Anesthetics, Intravenous Electrochemical Techniques Feedback Models, Theoretical Propofol

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