The yin-yang driving urinary tract infection and how proteomics can enhance research, diagnostics, and treatment.

Floyd KA, Meyer AE, Nelson G, Hadjifrangiskou M
Proteomics Clin Appl. 2015 9 (11-12): 990-1002

PMID: 26255866 · DOI:10.1002/prca.201500018

Bacterial urinary tract infections (UTIs) afflict millions of people worldwide both in the community and the hospital setting. The onset, duration, and severity of infection depend on the characteristics of the invading pathogen (yin), as well as the immune response elicited by the infected individual (yang). Uropathogenic Escherichia coli (UPEC) account for the majority of UTIs, and extensive investigations by many scientific groups have elucidated an elaborate pathogenic UPEC life cycle, involving the occupation of extracellular and intracellular niches and the expression of an arsenal of virulence factors that facilitate niche occupation. This review will summarize the current knowledge on UPEC pathogenesis; the host immune responses elicited to combat infection; and it will describe proteomics approaches used to understand UPEC pathogenesis, as well as drive diagnostics and treatment options. Finally, new strategies are highlighted that could be applied toward furthering our knowledge regarding host-bacterial interactions during UTI.

© 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

MeSH Terms (7)

Animals Host-Pathogen Interactions Humans Incidence Proteomics Urinary Tract Infections Uropathogenic Escherichia coli

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