Oxidative cyclizations in orthosomycin biosynthesis expand the known chemistry of an oxygenase superfamily.

McCulloch KM, McCranie EK, Smith JA, Sarwar M, Mathieu JL, Gitschlag BL, Du Y, Bachmann BO, Iverson TM
Proc Natl Acad Sci U S A. 2015 112 (37): 11547-52

PMID: 26240321 · PMCID: PMC4577193 · DOI:10.1073/pnas.1500964112

MeSH Terms (20)

Aminoglycosides Anti-Bacterial Agents Catalytic Domain Crystallography, X-Ray Cyclization Hydrogen Hygromycin B Metals Micromonospora Multigene Family Oligosaccharides Open Reading Frames Oxidation-Reduction Oxygen Oxygenases Phylogeny Protein Binding Protein Structure, Secondary Reproducibility of Results Streptomyces

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