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Inflammation and hypoxia in the kidney: friends or foes?

Haase VH
Kidney Int. 2015 88 (2): 213-5

PMID: 26230196 · PMCID: PMC4534718 · DOI:10.1038/ki.2015.89

Hypoxic injury is commonly associated with inflammatory-cell infiltration, and inflammation frequently leads to the activation of cellular hypoxia response pathways. The molecular mechanisms underlying this cross-talk during kidney injury are incompletely understood. Yamaguchi and colleagues identify CCAAT/enhancer-binding protein δ as a cytokine- and hypoxia-regulated transcription factor that fine-tunes hypoxia-inducible factor-1 signaling in renal epithelial cells and thus provide a novel molecular link between hypoxia and inflammation in kidney injury.

MeSH Terms (9)

Animals CCAAT-Enhancer-Binding Protein-delta Gene Expression Regulation Humans Hypoxia Hypoxia-Inducible Factor 1, alpha Subunit Kidney Male Nephritis

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