Demonstration of monoamine oxidase-A and -B in the human brainstem by a histochemical technique.

Konradi C, Kornhuber J, Froelich L, Fritze J, Heinsen H, Beckmann H, Schulz E, Riederer P
Neuroscience. 1989 33 (2): 383-400

PMID: 2622533 · DOI:10.1016/0306-4522(89)90218-2

The distribution of both monoamine oxidase subtypes, monoamine oxidase-A and -B, is demonstrated in brainstems from 16 humans by use of a histochemical technique. The results presented here, focus primarily upon the aminergic areas of the substantia nigra, the locus coeruleus and the raphe nuclei. While dopaminergic neurons of the substantia nigra revealed no staining for monoamine oxidase, noradrenergic neurons of the locus coeruleus stained positively with the monoamine oxidase-A substrate serotonin, and serotonergic neurons of the raphe nuclei were stained by the monoamine oxidase-B substrate beta-phenylethylamine. In addition, data are presented showing that glial cells stain predominantly for monoamine oxidase-B.

MeSH Terms (13)

Adolescent Adult Aged Brain Stem Child Child, Preschool Female Histocytochemistry Humans Infant Male Middle Aged Monoamine Oxidase

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