Further optimization of the mGlu5 PAM clinical candidate VU0409551/JNJ-46778212: Progress and challenges towards a back-up compound.

Zhou Y, Malosh C, Conde-Ceide S, Martínez-Viturro CM, Alcázar J, Lavreysen H, Mackie C, Bridges TM, Daniels JS, Niswender CM, Jones CK, Macdonald GJ, Steckler T, Conn PJ, Stauffer SR, Bartolomé-Nebreda JM, Lindsley CW
Bioorg Med Chem Lett. 2015 25 (17): 3515-9

PMID: 26183084 · PMCID: PMC4535329 · DOI:10.1016/j.bmcl.2015.06.096

MeSH Terms (7)

Allosteric Regulation Drug Discovery Humans Molecular Structure Receptor, Metabotropic Glutamate 5 Schizophrenia Structure-Activity Relationship

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