Proteolytic cleavage and loss of function of biologic agents that neutralize tumor necrosis factor in the mucosa of patients with inflammatory bowel disease.

Biancheri P, Brezski RJ, Di Sabatino A, Greenplate AR, Soring KL, Corazza GR, Kok KB, Rovedatti L, Vossenkämper A, Ahmad N, Snoek SA, Vermeire S, Rutgeerts P, Jordan RE, MacDonald TT
Gastroenterology. 2015 149 (6): 1564-1574.e3

PMID: 26170138 · DOI:10.1053/j.gastro.2015.07.002

MeSH Terms (23)

Adalimumab Antibodies, Monoclonal, Humanized Biological Factors Biopsy Case-Control Studies Colitis, Ulcerative Colon Crohn Disease Epitopes Etanercept Female Humans Immunoblotting Immunoglobulin G Inflammatory Bowel Diseases Infliximab Intestinal Mucosa Male Matrix Metalloproteinase 3 Matrix Metalloproteinase 12 Middle Aged Proteolysis Tumor Necrosis Factor-alpha

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