Chronic invasive fungal sinusitis associated with intranasal drug use.

Pekala KR, Clavenna MJ, Shockley R, Weiss VL, Turner JH
Laryngoscope. 2015 125 (12): 2656-9

PMID: 26153255 · PMCID: PMC4725714 · DOI:10.1002/lary.25429

Chronic invasive fungal sinusitis (CIFS) is a rare but potentially aggressive form of invasive fungal disease that occurs in immunocompetent patients. We report a case of CIFS in an otherwise healthy young adult associated with intranasal illicit drug abuse. The patient presented with nonhealing nasal septal and palatal perforations. Biopsy demonstrated invasive Aspergillus flavus requiring surgical debridement and extended intravenous antifungal therapy. Tissue necrosis and ulceration related to intranasal drug use should be recognized as a potential risk factor for invasive fungal sinusitis.

© 2015 The American Laryngological, Rhinological and Otological Society, Inc.

MeSH Terms (10)

Administration, Intranasal Aspergillosis Aspergillus flavus Debridement Humans Male Nasal Surgical Procedures Sinusitis Substance-Related Disorders Young Adult

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