Insulin-mediated signaling promotes proliferation and survival of glioblastoma through Akt activation.

Gong Y, Ma Y, Sinyuk M, Loganathan S, Thompson RC, Sarkaria JN, Chen W, Lathia JD, Mobley BC, Clark SW, Wang J
Neuro Oncol. 2016 18 (1): 48-57

PMID: 26136493 · PMCID: PMC4677408 · DOI:10.1093/neuonc/nov096

MeSH Terms (18)

Animals Antigens, CD Brain Neoplasms Cell Proliferation Cell Survival Female Glioblastoma Humans Insulin Insulin-Like Growth Factor I Insulin-Like Growth Factor II Mice, Nude Proto-Oncogene Proteins c-akt Receptor, IGF Type 1 Receptor, Insulin Receptors, Somatomedin Signal Transduction Tumor Cells, Cultured

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