Fabrication of 3D Scaffolds with Precisely Controlled Substrate Modulus and Pore Size by Templated-Fused Deposition Modeling to Direct Osteogenic Differentiation.

Guo R, Lu S, Page JM, Merkel AR, Basu S, Sterling JA, Guelcher SA
Adv Healthc Mater. 2015 4 (12): 1826-32

PMID: 26121662 · PMCID: PMC4558627 · DOI:10.1002/adhm.201500099

Scaffolds with tunable mechanical and topological properties fabricated by templated-fused deposition modeling promote increased osteogenic differentiation of bone marrow stem cells with increasing substrate modulus and decreasing pore size. These findings guide the rational design of cell-responsive scaffolds that recapitulate the bone microenvironment for repair of bone damaged by trauma or disease.

© 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

MeSH Terms (10)

Animals Cell Differentiation Cell Movement Cell Proliferation Cells, Cultured Mesenchymal Stem Cells Osteogenesis Rats Rats, Sprague-Dawley Tissue Scaffolds

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