Metabolomics analysis identifies novel plasma biomarkers of cystic fibrosis pulmonary exacerbation.

Laguna TA, Reilly CS, Williams CB, Welchlin C, Wendt CH
Pediatr Pulmonol. 2015 50 (9): 869-77

PMID: 26115542 · DOI:10.1002/ppul.23225

Cystic fibrosis (CF) lung disease is characterized by infection, inflammation, lung function decline, and intermittent pulmonary exacerbations. However, the link between pulmonary exacerbation and lung disease progression remains unclear. Global metabolomic profiling can provide novel mechanistic insight into a disease process in addition to putative biomarkers for future study. Our objective was to investigate how the plasma metabolomic profile changes between CF pulmonary exacerbation and a clinically well state.

MeSH Terms (17)

Adolescent Adult Biomarkers Cohort Studies Cystic Fibrosis Cytidine Female Humans Hydrocortisone Hypoxanthine Male Mannose Matched-Pair Analysis Metabolome Metabolomics Methionine Young Adult

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