Prevalence of Hypertension in Pediatric Tibia Vara and Slipped Capital Femoral Epiphysis.

Taussig MD, Powell KP, Cole HA, Nwosu SK, Hunley T, Romine SE, Iwinski H, Talwalkar V, Warhoover T, Lovejoy SA, Mencio GA, Martus JE, Walker J, Milbrandt T, Schoenecker JG
J Pediatr Orthop. 2016 36 (8): 877-883

PMID: 26090984 · DOI:10.1097/BPO.0000000000000569

BACKGROUND - Slipped capital femoral epiphysis (SCFE) and tibia vara (Blount disease) are associated with childhood obesity. However, the majority of obese children do not develop SCFE or tibia vara. Therefore, it is hypothesized that other obesity-related biological changes to the physis, in addition to increased biomechanical stress, potentiate the occurrence of SCFE and tibia vara. Considering that hypertension can impose pathologic changes in the physis similar to those observed in these obesity-related diseases we set out to determine the prevalence of hypertension in patients with SCFE and tibia vara.

METHODS - Blood pressure measurements were obtained in 44 patients with tibia vara and 127 patients with SCFE. Body mass index and blood pressure were adjusted for age, sex, and height percentiles utilizing normative distribution data from the CDC. These cohorts were compared with age-matched and sex-matched cohorts derived from an obesity clinic who did not have either bone disease. A multivariable proportional odds model was used to determine association.

RESULTS - The prevalence of prehypertension/hypertension was significantly higher in the tibia vara (64%) and SCFE cohort (64%) compared with respective controls (43%). Patients diagnosed with either SCFE or tibia vara had 2.5-fold higher odds of having high blood pressure compared with age-matched and sex-matched obese patients without bone disease. Sex, age, and race did not have a significant effect on a patient's blood pressure.

CONCLUSIONS - This is the first study to establish that the obesity-related bone diseases, SCFE and tibia vara, are significantly associated with high blood pressure. These data have immediate clinical impact as they demonstrate that children with obesity-related developmental bone disease have increased prevalence of undiagnosed and untreated hypertension. Furthermore, this prevalence study supports the hypothesis that hypertension in conjunction with increased biomechanical forces together potentiate the occurrence of SCFE and tibia vara. If proven true, it is plausible that hypertension may represent a modifiable risk factor for obesity-related bone disease.

LEVEL OF EVIDENCE - Level III-case-control study.

MeSH Terms (14)

Adolescent Blood Pressure Bone Diseases, Developmental Child Child, Preschool Female Humans Hypertension Male Osteochondrosis Prevalence Risk Factors Slipped Capital Femoral Epiphyses United States

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