Selenoprotein P influences colitis-induced tumorigenesis by mediating stemness and oxidative damage.

Barrett CW, Reddy VK, Short SP, Motley AK, Lintel MK, Bradley AM, Freeman T, Vallance J, Ning W, Parang B, Poindexter SV, Fingleton B, Chen X, Washington MK, Wilson KT, Shroyer NF, Hill KE, Burk RF, Williams CS
J Clin Invest. 2015 125 (7): 2646-60

PMID: 26053663 · PMCID: PMC4563672 · DOI:10.1172/JCI76099

MeSH Terms (20)

Animals Antioxidants Apoptosis Colitis Colonic Neoplasms DNA Damage Genomic Instability Haploinsufficiency Macrophages Mice Mice, Inbred C57BL Mice, Knockout Mutagenesis, Site-Directed Neoplastic Stem Cells Oxidative Stress Protein Structure, Tertiary Selenium Selenoprotein P Tumor Microenvironment Tumor Suppressor Proteins

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