Fish, omega-3 long-chain fatty acids, and all-cause mortality in a low-income US population: Results from the Southern Community Cohort Study.

Villegas R, Takata Y, Murff H, Blot WJ
Nutr Metab Cardiovasc Dis. 2015 25 (7): 651-8

PMID: 26026210 · PMCID: PMC4557690 · DOI:10.1016/j.numecd.2015.04.006

BACKGROUND - We examined associations between fish and n-3 LCFA and mortality in a prospective study with a large proportion of blacks with low socio-economic status.

METHODS AND RESULTS - We observed 6914 deaths among 77,604 participants with dietary data (follow-up time 5.5 years). Of these, 77,100 participants had available time-to-event data. We investigated associations between mortality with fish and n-3 LCFA intake, adjusting for age, race, sex, kcal/day, body mass index (BMI), smoking, alcohol consumption, physical activity, income, education, chronic disease, insurance coverage, and meat intake. Intakes of fried fish, baked/grilled fish and total fish, but not tuna, were associated with lower mortality among all participants. Analysis of trends in overall mortality by quintiles of intake showed that intakes of fried fish, baked/grilled fish and total fish, but not tuna, were associated with lower risk of total mortality among all participants. When participants with chronic disease were excluded, the observed association remained only between intakes of baked/grilled fish, while fried fish was associated with lower risk of mortality in participants with prevalent chronic disease. The association between n-3 LCFA intake and lower risk of mortality was significant among those with diabetes at baseline. There was an inverse association of mortality with fried fish intake in men, but not women. Total fish and baked/grilled fish intakes were associated with lower mortality among blacks while fried fish intake was associated with lower mortality among whites. Effect modifications were not statistically significant.

CONCLUSION - Our findings suggest a modest benefit of fish consumption on mortality.

Copyright © 2015 Elsevier B.V. All rights reserved.

MeSH Terms (22)

African Continental Ancestry Group Age Factors Animals Cohort Studies Cooking Diabetes Mellitus Diet Diet Surveys Ethnic Groups European Continental Ancestry Group Fatty Acids, Omega-3 Female Fishes Humans Male Middle Aged Mortality Poverty Risk Factors Sex Factors Socioeconomic Factors United States

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