Perfusion and pH MRI in familial hemiplegic migraine with prolonged aura.

Blicher JU, Tietze A, Donahue MJ, Smith SA, Østergaard L
Cephalalgia. 2016 36 (3): 279-83

PMID: 25948653 · DOI:10.1177/0333102415586064

INTRODUCTION - To investigate tissue flow disturbance and hypoxia during migraine aura, we studied a case of familial hemiplegic migraine (FHM) using novel magnetic resonance imaging (MRI) techniques.

CASE RESULTS - A 44-year-old male was admitted with suspected stroke because of confusion and aphasia. Initial gadolinium-based perfusion MRI showed a decrease in cerebral blood flow and an increase in capillary flow disturbances within the left hemisphere. Later during the prolonged aura phase, chemical exchange saturation transfer MRI indicated a drop in pH in the affected area. The patient was diagnosed with an R908Q mutation in the ATP1A2 gene causing FHM type 2.

DISCUSSION - During prolonged aura in FHM, MRI shows reduced CBF, capillary flow disturbances and a possible pH drop that could indicate tissue hypoxia.

© International Headache Society 2015.

MeSH Terms (11)

Adult Cerebrovascular Circulation Humans Hydrogen-Ion Concentration Image Interpretation, Computer-Assisted Magnetic Resonance Imaging Male Migraine with Aura Mutation Pedigree Sodium-Potassium-Exchanging ATPase

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