Emerging structural insights into the function of ionotropic glutamate receptors.

Karakas E, Regan MC, Furukawa H
Trends Biochem Sci. 2015 40 (6): 328-37

PMID: 25941168 · PMCID: PMC4464829 · DOI:10.1016/j.tibs.2015.04.002

Ionotropic glutamate receptors (iGluRs) are ligand-gated ion channels that mediate excitatory neurotransmission crucial for brain development and function, including learning and memory formation. Recently a wealth of structural studies on iGluRs including AMPA receptors (AMPARs), kainate receptors, and NMDA receptors (NMDARs) became available. These studies showed structures of non-NMDARs including AMPAR and kainate receptor in various functional states, thereby providing the first visual sense of how non-NMDAR iGluRs may function in the context of homotetramers. Furthermore, they provided the first view of heterotetrameric NMDAR ion channels, and this illuminated the similarities with and differences from non-NMDARs, thus raising a mechanistic distinction between the two groups of iGluRs. We review mechanistic insights into iGluR functions gained through structural studies of multiple groups.

Copyright © 2015 Elsevier Ltd. All rights reserved.

MeSH Terms (10)

Brain Humans Ligand-Gated Ion Channels Protein Conformation Receptors, AMPA Receptors, Ionotropic Glutamate Receptors, Kainic Acid Receptors, N-Methyl-D-Aspartate Structure-Activity Relationship Synaptic Transmission

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