Biased mGlu5-Positive Allosteric Modulators Provide In Vivo Efficacy without Potentiating mGlu5 Modulation of NMDAR Currents.

Rook JM, Xiang Z, Lv X, Ghoshal A, Dickerson JW, Bridges TM, Johnson KA, Foster DJ, Gregory KJ, Vinson PN, Thompson AD, Byun N, Collier RL, Bubser M, Nedelcovych MT, Gould RW, Stauffer SR, Daniels JS, Niswender CM, Lavreysen H, Mackie C, Conde-Ceide S, Alcazar J, Bartolomé-Nebreda JM, Macdonald GJ, Talpos JC, Steckler T, Jones CK, Lindsley CW, Conn PJ
Neuron. 2015 86 (4): 1029-1040

PMID: 25937172 · PMCID: PMC4443790 · DOI:10.1016/j.neuron.2015.03.063

MeSH Terms (13)

Allosteric Regulation Animals Antipsychotic Agents Cognition Glutamic Acid HEK293 Cells Hippocampus Humans Male Rats, Sprague-Dawley Receptor, Metabotropic Glutamate 5 Receptors, N-Methyl-D-Aspartate Signal Transduction

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