An Fc engineering approach that modulates antibody-dependent cytokine release without altering cell-killing functions.

Kinder M, Greenplate AR, Strohl WR, Jordan RE, Brezski RJ
MAbs. 2015 7 (3): 494-504

PMID: 25933349 · PMCID: PMC4622058 · DOI:10.1080/19420862.2015.1022692

MeSH Terms (11)

Antibodies, Monoclonal Antibodies, Neoplasm Antibody-Dependent Cell Cytotoxicity Cell Line, Tumor Cytokines Humans Immunoglobulin Fc Fragments Macrophages Neoplasms Protein Engineering Tumor Microenvironment

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