Activated platelets express IL-1 activity.

Hawrylowicz CM, Santoro SA, Platt FM, Unanue ER
J Immunol. 1989 143 (12): 4015-8

PMID: 2592766

Suspensions of washed human platelets express IL-1 activity after activation with agents such as thrombin, collagen, ADP, or epinephrine as judged by the ability of the platelet suspensions to support the growth of a T cell line, D10.G4.1, which exhibits a growth requirement for IL-1. Unactivated platelets express little IL-1 activity. The IL-1 activity expressed by activated platelets appears to be entirely associated with the platelet surface. No IL-1 activity was detected in supernatants derived from suspensions of activated platelets. A mAb specific for IL-1 beta inhibited 90% of the activity expressed by thrombin-activated platelets, whereas a mAb specific for IL-1 alpha inhibited approximately 20% of the activity. A control mAb was without an effect. These results indicate that activated platelets express surface-associated IL-1 activity. Platelet surface IL-1 may provide a mechanism for altering in an extremely localized and rapid manner the properties of IL-1 responsive cells with which platelets come in direct contact during processes of inflammation and vessel wall damage.

MeSH Terms (12)

Animals Antibodies, Monoclonal Antibody Specificity Blood Platelets Cell Line Cytoplasmic Granules Humans Interleukin-1 Lymphocyte Activation Mice Platelet Activation T-Lymphocytes

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