Increased Prevalence of Sleep Apnea in Children with Pseudohypoparathyroidism Type 1a.

Landreth H, Malow BA, Shoemaker AH
Horm Res Paediatr. 2015 84 (1): 1-5

PMID: 25925491 · PMCID: PMC4540680 · DOI:10.1159/000381452

BACKGROUND/AIMS - Pseudohypoparathyroidism type 1a (PHP1a) is a rare genetic disorder. This study aimed to determine the prevalence of sleep apnea in children with PHP1a.

METHODS - Nineteen patients with PHP1a between the age of 2 and 21 years were enrolled prospectively using online advertisements. Parents completed a medical history and surveys to assess sleep behavior. Polysomnography records were obtained when available. In addition, 18 subjects were identified in a retrospective chart review of de-identified medical records with 2.3 million patient charts.

RESULTS - Parents reported sleep disturbance (94%) and daytime somnolence (81%) in their children with PHP1a. In the retrospective chart review, 39% had a history of sleep apnea versus 8.8% of a similarly obese control group. In the combined analysis (n = 31), 52% had a history of snoring and 45% had a diagnosis of sleep apnea. Patients were obese with a mean BMI z-score of 2.20 ± 0.59. Patients with sleep apnea were significantly younger than those without a diagnosis (8.1 ± 5.4 vs. 12.8 ± 5.0 years, p = 0.02).

CONCLUSIONS - Children with PHP1a have a 4.4-fold greater relative risk of sleep apnea than similarly obese children. Screening for sleep apnea in this population may be warranted to prevent adverse health outcomes.

© 2015 S. Karger AG, Basel.

MeSH Terms (11)

Adolescent Child Female Humans Male Obesity Polysomnography Prevalence Pseudohypoparathyroidism Risk Factors Sleep Apnea Syndromes

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