VFV as a New Effective CYP51 Structure-Derived Drug Candidate for Chagas Disease and Visceral Leishmaniasis.

Lepesheva GI, Hargrove TY, Rachakonda G, Wawrzak Z, Pomel S, Cojean S, Nde PN, Nes WD, Locuson CW, Calcutt MW, Waterman MR, Daniels JS, Loiseau PM, Villalta F
J Infect Dis. 2015 212 (9): 1439-48

PMID: 25883390 · PMCID: PMC4601915 · DOI:10.1093/infdis/jiv228

MeSH Terms (22)

Animals Antiprotozoal Agents Benzamides Biotransformation Chagas Disease Cytochrome P-450 Enzyme Inhibitors Cytochrome P-450 Enzyme System Disease Models, Animal Female Humans Imidazoles Inhibitory Concentration 50 Leishmaniasis, Visceral Mice Mice, Inbred BALB C Microsomes, Liver Molecular Structure Oxadiazoles Rats Structure-Activity Relationship Tissue Distribution Trypanosoma cruzi

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